A high-content cellular senescence screen identifies candidate tumor suppressors, including EPHA3
نویسندگان
چکیده
منابع مشابه
A high-content cellular senescence screen identifies candidate tumor suppressors, including EPHA3
Activation of a cellular senescence program is a common response to prolonged oncogene activation or tumor suppressor loss, providing a physiological mechanism for tumor suppression in premalignant cells. The link between senescence and tumor suppression supports the hypothesis that a loss-of-function screen measuring bona fide senescence marker activation should identify candidate tumor suppre...
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ژورنال
عنوان ژورنال: Cell Cycle
سال: 2013
ISSN: 1538-4101,1551-4005
DOI: 10.4161/cc.23515